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Sun Pharma, società farmaceutica multinazionale con sede a Mumbai, in India, ha avviato un richiamo volontario di lotti multipli di “BUPROPIONE” cloridrato prolungato compresse USP (SR), 200mg, flacone da 60, dal mercato statunitense usato per trattare la depressione evitando così il sequestro dal mercato statunitense. Questa decisione è stata presa, in seguito a nuove scoperte effettuate con prove cliniche che mostrano una mancanza di efficacia e rimettono in discussione il profilo rischio-beneficio del prodotto. Secondo un comunicato diffuso dal USFDA, l’agenzia statunitense che regola alimenti, bevande ed integratori alimentari per il consumo animale ed umano, nessun trattamento deve essere iniziato a nuovi pazienti dopo che la ditta produttrice ha comunicato alcuni risultati fuori specifica per i parametri di dissoluzione e disgregazione. Si tratta di un farmaco antidepressivo atipico appartenente alla famiglia dei catinoni sostituti o sintetici (β-chetoamfetamine) e delle amfetamine sostitute. Il farmaco esercita una leggera attività psicostimolante. Si ritiene che bupropione eserciti a sua azione farmacologica inibendo la ricaptazione della dopamina e della noradrenalina. Il farmaco si lega selettivamente al trasportatore della dopamina (DAT), ma i suoi effetti sono stati spesso attribuiti al reuptake della noradrenalina.Agisce anche come antagonista dei recettori dell’acetilcolina di tipo nicotinico.Questa sua azione viene sfruttata come sostegno nella cessazione all’abitudine al fumo di sigaretta, poiché il farmaco diminuisce il craving ed il piacere indotto dalla nicotina (che invece è un agonista dei recettori colinergici). Il bupropione appartiene alla classe degli aminochetoni e la sua struttura è simile agli stimolanti catinone, dietilpropione e alle fenetilamine in generale. In Italia il farmaco è commercializzato come aiuto alla cessazione dell’abitudine al fumo di sigaretta dalla società farmacologica GlaxoSmithKline con il nome commerciale di Zyban, nella forma farmaceutica di compresse da 150 mg. La medesima società con la controllata Glaxo Allen commercializza la molecola come antidepressivo, in compresse a rilascio modificato da 150 mg e 300 mg, con il nome di Wellbutrin ed Elontril. Il bupropione abbassa la soglia convulsiva, e questa sua azione facilitante nel causare crisi epilettiche è stata ampiamente pubblicizzata. Tuttavia, alla dose raccomandata, il rischio di convulsioni è paragonabile a quello osservato per altri antidepressivi. Alla luce di tale comunicazione, Giovanni D’Agata, presidente dello “Sportello dei Diritti”, rivolge un invito al Ministero della Salute affinché avvii tutte le iniziative opportune per monitorare la consistenza del richiamo anche in Italia ed eventualmente prendere le misure idonee sulla falsariga di quanto sta facendo la USFDA in America.
/ Novità / FUORI TEMA – La moto è un antidepressivo naturale?
Quante volte, quando siamo stressati o infelici o semplicemente fuori fase, prendiamo la nostra amata motocicletta? Ce ne andiamo a fare due colli e riacquistiamo il sorriso, torniamo a casa più sereni e pronti ad affrontare le difficoltà che, soprattutto di questi tempi, la vita ci presenta. La motocicletta si può perciò definire una sorta di antidepressivo naturale? Secondo la maggior parte dei motociclisti che ho intervistato sicuramente sì. Le due ruote sembrano essere un ottimo antidoto allo stress ed alle difficoltà; soprattutto un rimedio senza effetti collaterali conosciuti, salvo forse quelli ortopedici quando oltre alla serenità cerchiamo anche l’adrenalina. Tuttavia è abbastanza ovvio che i motociclisti la pensino così, perciò, come ogni bravo giornalista deve fare, mi sono messo alla ricerca di conferme ed ho scovato una indagine inglese abbastanza recente che sostanzia questa ipotesi e dimostra che i motociclisti hanno un approccio alla vita più positivo.
L’indagine inglese – In Gran Bretagna ogni anno viene svolto l’Annual Population Survey (APS), un questionario diffuso a gran parte della popolazione utile a valutare la qualità della vita. Nel 2014, fra le tante domande concentrate principalmente sulla soddisfazione personale poste agli oltre 60.000 intervistati, sono stati evidenziati anche i pareri dei motociclisti, che si sono rivelati i più soddisfatti della propria vita e i più rilassati, soprattutto quelli che usano le due ruote per andare al lavoro tutti i giorni. L’elemento che distingue il motociclista dagli altri pendolari è senza dubbio il fattore “passione”: iniziare la giornata su due ruote, anche se nel traffico della città, aiuta ad essere meno stressati durante l’orario di lavoro. Stesso discorso per il ritorno: dopo una dura giornata stare imbottigliati nel traffico con l’auto o incastrati in metro è decisamente più stressante dell’affrontare la stessa strada in sella.
L’indagine inglese
Il parere del medico – Per una ulteriore verifica ho anche consultato una psicologa clinica e le ho posto il quesito del titolo. “Come tutte le passioni – ha evidenziato la Dott.ssa Roberta Giangrande – anche quella per le due ruote permette di sentirsi protagonisti attivi della propria vita, di provare piacere per quello che si sta facendo; inoltre espone le persone agli effetti benevoli degli stimoli esterni positivi, come i paesaggi naturali, e permette di socializzare e di non cadere vittime della solitudine. Per questi motivi questa passione non può che migliore in generale la qualità della vita personale permettendo di abbassare notevolmente il rischio di stati depressivi esogeni.” Fin qui tutto bene, ma molti motociclisti (io sono uno di quelli) sono dei fanatici che non riescono a stare lontani dalla moto. “Se subentra una forma così compulsiva – ha concluso la Dott.ssa Giangrande – per cui non si può più fare a meno di utilizzare il mezzo, anzi è il mezzo che utilizza noi, allora si può ribaltare seriamente la situazione; a quel punto l’impossibilità di usare il mezzo può diventare un trampolino verso la depressione.”
The longtime partner of Harry Potter actor Daniel Radcliffe, Erin Darke, has announced they are expecting their first child together.
From Wizarding to Diapers
The news of Daniel Radcliffe’s impending fatherhood was revealed by the British actor’s agent on March 26. Radcliffe is best known as the hero of the popular Harry Potter film series.
The 33-year-old, whom we all grew up following his antics in the wild realm of witchcraft and magic, was essentially the face of our childhoods.
The duo has been known to encourage one another in their separate ventures while choosing to maintain a relatively quiet profile about their relationship.
Daniel and Erin later reconnected on the set of the dramedy Don’t Think Twice in 2016, following their collaboration on Kill Your Darlings.
Thus, learning that he is now raising a child on his own is unexpected.
They’ll make good parents
After meeting while filming Kill Your Darlings, a drama/romance movie about the Beat Generation, in 2013, Radcliffe and Darke, both 38, have been dating for almost ten years.
With Darke portraying Gwendolyn, Radcliffe played the moody poet Allen Ginsberg.
What a beautiful meet-cute.
In an interview with Marie Claire from 2015, Radcliffe talked about the moment they both caught one other’s gaze for the first time.
Radcliffe said, “That’s a great record of us flirting for the first time. Nothing is being done—at least not on my end.
He continued by expressing his appreciation for their sincere connection and said, “There’s a point when she makes me laugh, and I’m laughing as me and not as my role.
I knew I was in trouble because she was so hilarious and intelligent.
Ten years later, the adorable pair is about to embark on a brand-new journey.
Radcliffe made it plain that he has been considering fatherhood for some time when he told Newsweek in October of last year, “I want my kids – if and when they exist – I would love for them to be around film sets.”
But, it’s evident the singer wants something a little different for his future child than his famous and successful childhood did when he was just 12-years-old.
He said, “I wouldn’t want celebrity for my baby.” The famous side of film sets is actually what should be avoided at all costs, despite the fact that they are sometimes fantastic locations for youngsters.
According to the Mirror, an actor’s representative confirmed Radcliffe’s good news last night (March 25).
Daniel and Erin could not be happier to be expecting, according to a source close to the pair. They are ecstatic and eager to expand their family to three members.
It’s an immensely exciting time, as they recently informed their relatives and friends.
It is obvious that the news caused elation among all Potterheads and wasn’t just thrilling for the couple.
“Congratulations to them but I feel ancient today,” one Twitter user wrote.
Do we not all?
Another obviously overjoyed admirer added, “Harry Potter’s going to be a dad!!!”
“Daniel Radcliffe is going to be a dad. Why does this feel like the official event that ends my childhood?” a third person chimed in.
Harry, you’re a father!
The first city in the UK to start charging visitors is Manchester.
Enhancing Visitor Experience
The municipal visitor charge, sometimes known as the tourist tax, intends to earn millions of pounds to be used for “enhancing the visitor experience.”
The decision is in line with those made by European towns like Barcelona and Venice.
Visitors staying at hotels in the city center will be charged £1 per night, per room, starting on April 1.
The new Manchester Accommodation Business Improvement District (ABID), which intends to “promote future growth of the visitor economy” over the next five years, will benefit from the scheme’s anticipated £3 million in annual revenue.
Everything has taxes now
The Manchester Accommodation BID is a groundbreaking new effort led by the city’s hotel and serviced apartment providers to help generate new events and extracurricular activities that will draw more tourists to visit and stay in Manchester and Salford, according to the Manchester ABID website.
Additionally, it will serve to improve the entire guest experience and develop the city’s tourism industry by:
-boosting advertising initiatives that encourage overnight stays;
-arranging large-scale occasions, conferences, and festivals during off-peak times;
-increasing street cleanliness and welcoming guests.
The City Visitor Charge, a supplemental £1 Fee per room/unit per night* for visitors, will be used to pay for the aforementioned events.
On 1 April 2023, all reservations made at establishments that charge for lodging and are located in the Manchester Accommodation BID zone will be subject to the mandatory charge.
The tax, according to ABID head Annie Brown, will help the city and tourists.
She told the Manchester Evening News: “We feel it’s a minor sum relative to other European cities that have taxes and visitor charges in place for a period of years, although [the message it sends] has been considered.
“Manchester has done something that other cities in the UK are looking to implement; I don’t think it’s a fee that’s off-putting.”
She went on: “It’s well known that we have a rising number of hotels opening, so it’s critical that we maintain our growth and position ourselves as a destination.
“There are several strategies to accomplish this, but the two most effective ones revolve around holding city events during “shoulder periods,” or slower times of the year, and luring major events to the area.
We are aware that we are competing against other major cities not just in the UK but all around the world, whether it be for major athletic, musical, or conference events.
Even though Annie is originally from Australia, it is evident that Manchester has captured her heart, and she welcomes tourists to come and experience for themselves.
In the end, she remarked, “I feel so passionately about Manchester, even though I’m not from Manchester, what greater thing is there to be involved in – presenting Manchester to the world.
Because it’s such an exciting, dynamic, and active city that’s wonderful from a professional and leisure viewpoint, it’s my favorite place I’ve worked in in the UK.
There has never been a better moment to visit Manchester because there are so many options available on every level.
Fans of the wizarding world franchise who are seeking for the next big thrill will be thrilled to learn that the world’s largest indoor Harry Potter-themed attraction is about to open.
The land of the Potterheads
Warner Bros. The date of the Warner has been revealed by Discovery. Bros. The Making of Harry Potter Studio Tour Tokyo will debut in Japan.
Billed as the world’s largest indoor Harry Potter attraction, it is slated to open its doors this summer, on Friday June 16. On March 22, tickets will go on sale. It is also expected to be the first Warner Bros. Asia Studio Tour.
The attraction will be situated where the Toshimaen amusement park in Nerima, Tokyo, which closed in August 2020, once stood. It will offer unique sets and experiences.
With realistic sets, costumes, and props, a chance to explore the worlds of Diagon Alley and Platform 9 34, as well as exclusive sets not present at any other Warner Bros. attractions, the attraction will provide the customary enchantment and fantasy visitors have come to anticipate from Harry Potter. website studios.
The attraction will also include significant elements and sizable movie sets from the Fantastic Beasts series, so it’s not just the Harry Potter books and movie sets that will be on exhibit.
Filmmakers who worked on the first Harry Potter movie series expressly commissioned and made several of the movie sets for the new attraction even though they weren’t technically used in the movies.
Get your wands on!
Beginning on June 16, Tokyo, Japan will offer a fresh opportunity to explore the wizarding and magical worlds. This won’t be the first Warner Bros. The largest indoor Harry Potter attraction in the world, Studio Tour, will debut in Asia.
The new attraction will also have interactive experiences, such as green screen exhibits that let visitors act out important movie events, for Harry Potter fans who want to feel like they’re “in” the movies. One memorable experience will be the chance to board the Hogwarts Express, a must-do for diehard Potterheads.
Those who are eager to attend will need to act quickly, as tickets for the opening event go on sale via the official website on March 22.
Only tickets purchased in advance will be able to enter the enormous new universe, with prices ranging from 3,800 (£23.68) for youngsters under the age of four to 5,200 (£32.40) for those between the ages of 12 and 17. Tickets for enthusiastic adults cost 6,300 (£39.25).
Despite the first Harry Potter book and movie being published in 1997 and 2001, respectively, the world established by author J.K. Rowling has persisted in captivating and enchanting readers all over the world. Devoted American viewers even went so far as to recast the entire movie with Americans rather than the currently well-known stars.
The intelligent fans recast every character from the first movie, Harry Potter and the Philosopher’s Stone, and made it an entirely American version through a series of votes.
A Child’s On the Way for Harry Potter Star, Daniel Radcliffe
Manchester Becomes the First City in the UK to Tax Visitors
A Child’s On the Way for Harry Potter Star, Daniel Radcliffe
Manchester Becomes the First City in the UK to Tax Visitors
This Summer, The Biggest Indoor Harry Potter Attraction in the World will Debut
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